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本文报导,从日本东北甘草分离得到的甘草抗胃溃疡成分甘草酮(Licoricone,Ⅱ)的结构鉴定。甘草酮(Ⅱ)为熔点250～251°的无色针状结晶。经元素、质谱分析其分子式为 C_(22)H_(22)O_6,经紫外吸收光谱、核磁共振光谱推定为异黄酮衍生物,并根据核磁共振光谱和质谱的分析提出(Ⅰ)的部分结构,B 环的置换形式有11种可能性。因此,将Ⅰ制成Ⅱ的一溴化乙酸盐(Ⅲ)进行-X 射线衍射分析,结果测得如图所示的分子结构并确定了甘草酮的结构为Ⅱ。
This paper reports the structural identification of Licoricone (Licoricone, Ⅱ), a component of licorice antigastric ulcer isolated from Glycyrrhiza uralensis, Japan. Glycyrrhizin (II) is a colorless needle-shaped crystal with a melting point of 250 to 251 °. The molecular structure of the compound was C 22 H 22 O 6 by elemental and mass spectrometry, and was identified as isoflavone derivatives by ultraviolet absorption and nuclear magnetic resonance spectroscopy. The partial structure of (Ⅰ) was proposed based on the analysis of nuclear magnetic resonance spectroscopy and mass spectrometry. There are 11 possibilities for the substitution of the B ring. Therefore, X-ray diffraction analysis of the monobromoacetate salt (III) prepared from II to II showed the molecular structure as shown in the figure and the structure of the glycyrrhizin was determined as II.