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目的调查青岛市沿海社区10年以上居民高尿酸血症与痛风的流行情况,为治疗和预防提供临床依据。方法采用整群抽样的方法,在青岛市崂山区社区调查了5658名居民高尿酸血症与痛风的患病情况,并进行血尿酸、空腹血糖、血清胆固醇、甘油二三酯及肝肾功能的检查。结果正常人群男性血尿酸平均(288±67)μmol/L、女性平均(223±48)μmol/L;高尿酸血症患病率为5.46%(标化后4.75%),男性9.21%(标化后8.23%)、女性为1.34%(标化后1.14%);高尿酸者男性血尿酸水平平均(457±26)μmol/L,女性平均(390±30)μmol/L。男、女平均患病年龄分别为52.1岁、54.8岁;痛风患病率为0.99%(标化后0.862%),男性为1.59%(标化后1.42%),女性为0.33%(标化后0.28%)。高尿酸者中痛风的患病率为15.26%,男性为17.22%,女性为9.57%。调查发现海鲜及啤酒是诱发青岛市社区痛风的主要原因;高尿酸血症伴发疾病中以高脂血症最为常见,其次为原发性高血压、糖尿病、冠心病;痛风的首发部位常见的是第一跖趾关节,其次为足背、距小腿关节、膝关节;最常见的部位是拇趾及第一跖趾关节,其次为踝、足背、膝、腕、指、肘等关节。结论青岛市沿海社区人群高尿酸血症及痛风患病率不高于国内其他地区的调查结果。
Objective To investigate the prevalence of hyperuricemia and gout in residents of coastal communities in Qingdao for more than 10 years, and provide a clinical basis for treatment and prevention. Methods A cluster sampling method was used to investigate the prevalence of hyperuricemia and gout in 5658 residents of Laoshan district of Qingdao City. The prevalence of blood uric acid, fasting blood glucose, serum cholesterol, triglycerides and liver and kidney function an examination. Results The mean serum uric acid was (288 ± 67) μmol / L in normal men and 223 ± 48 μmol / L in females respectively. The prevalence of hyperuricemia was 5.46% (4.75%) and 9.21% 8.23% post-chemotherapy) and 1.34% for women (1.14% post-standardization). The serum uric acid level was significantly higher in hypertensive men (457 ± 26) μmol / L and in female than in women (390 ± 30) μmol / L. The average prevalence of males and females was 52.1 years and 54.8 years respectively. The prevalence of gout was 0.99% (normalized to 0.862%) in men and 1.59% (normalized to 1.42%) and 0.33% in females (normalized 0.28%). The prevalence of gout among those with high uric acid was 15.26%, 17.22% for men and 9.57% for women. The survey found that seafood and beer are the main causes of gout in Qingdao community induced; hyperuricemia associated with hyperlipidemia in the most common disease, followed by primary hypertension, diabetes, coronary heart disease; the first part of the common gout Is the first metatarsophalangeal joint, followed by the dorsal foot, from the lower leg joint, knee joint; the most common site is the big toe and the first metatarsophalangeal joint, followed by the ankle, dorsal, knees, wrists, fingers, elbows and other joints. Conclusion The prevalence of hyperuricemia and gout in coastal communities in Qingdao is not higher than that in other parts of China.