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目的探讨低分子肝素口服制剂对肝损伤家兔血液流变学及肝脏微循环的影响．方法家兔３０只随机分为Ａ组（正常对照）、Ｂ组（仅腹腔注射Ｄ－氨基半乳糖）、Ｃ组（低分子肝素治疗组），测定其血液流变学并观察肝脏微循环改变．结果用药后２４ｈ和７２ｈ观察，同Ａ组相比，Ｂ组平均血流量（１７４±５２，１４２±１４ｖｓ３２５±１０１，Ｐ＜００１）和极差（２３±１４，１３±０６ｖｓ４３±２７，Ｐ＜００５）明显降低，低切粘度（１０１１ｍＰａ·Ｓ－１±０５６ｍＰａ·Ｓ－１，８０４ｍＰａ·Ｓ－１±０７５ｍＰａ·Ｓ－１ｖｓ７２８ｍＰａ·Ｓ－１±０６１ｍＰａ·Ｓ－１，Ｐ＜００５）、高切粘度（５０４ｍＰａ·Ｓ－１±０３６ｍＰａ·Ｓ－１ｖｓ４７５ｍＰａ·Ｓ－１±０２７ｍＰａ·Ｓ－１，Ｐ＜００５）、血浆粘度（１７５ｍＰａ·Ｓ－１±０１３ｍＰａ·Ｓ－１ｖｓ１６９ｍＰａ·Ｓ－１±００９ｍＰａ·Ｓ－１Ｐ＜００５）、红细胞聚集指数（２０７±０１３，１９１±０３７ｖｓ１３６±００８，Ｐ＜００１）明显升高，血沉和红细胞压积无显著改变．Ｃ组同Ｂ组相比，高切粘度（４３８ｍＰａ·Ｓ－１±０?
Objective To investigate the effect of low molecular weight heparin oral preparation on hemorrheology and hepatic microcirculation in rabbits with liver injury. Methods Thirty rabbits were randomly divided into group A (normal control), group B (intraperitoneal injection of D-galactosamine only) and group C (low molecular weight heparin treatment group). The hemorheology was measured and the change of hepatic microcirculation . Results 24h and 72h after treatment, compared with group A, the average blood flow in group B (174 ± 52, 142 ± 14 vs 325 ± 101, P <001) and pole The difference (23 ± 14, 13 ± 06vs43 ± 27, P <005) was significantly lower, and the low shear viscosity (1011mPa · S-1 ± 056mPa · S -1,804mPa · S -1 ± 075mPa · S-1vs728mPa · S -1 ± 061mPa · S-1, P <005), high shear viscosity (504mPa · S- 1 ± 036mPa · S-1vs475mPa · S-1 ± 027mPa · S-1, P <005), plasma viscosity (175mPa · S-1 ± 013mPa · S-1vs1 69mPa · S-1 ± 009mPa · S-1P <005), erythrocyte aggregation index (20 ± 013, 191 ± 037 vs1 36 ± 0 08, P <0 01) was significantly increased, hematopoietic and hematocrit no significant change. C group compared with the B group, the high shear viscosity (4 38mPa · S-1 ± 0 ?