六十年代中期,医学领域中出现了一个崭新的课题:自由基(FR)及脂质过氧化作用(LPO)与疾病发生的关系。七十年代以后,国外学者开始探讨氧FR在缺血性心脏病发生过程中的作用及FR拮抗剂对心脏的保护作用。比较一致的看法是:心肌缺血通过一系列至今尚有争议的机制引起FR和LPO增强,进而损伤细胞的膜系统,破坏其功能,导致细胞死亡,使心肌可逆性缺血损伤转变为不可逆性坏死。 In the mid-1960s, a brand new topic emerged in medicine: the relationship between free radicals (FR) and lipid peroxidation (LPO) and disease. After the seventies, foreign scholars began to explore the role of oxygen FR in the pathogenesis of ischemic heart disease and the protective effect of FR antagonist on the heart. A more consistent view is that myocardial ischemia leads to enhanced FR and LPO through a series of controversial mechanisms that have hitherto been controversial, further damaging the cellular membrane system, disrupting its function, leading to cell death, reversing irreversible myocardial reversible ischemic damage Necrosis.