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目的 探讨非典型EB病毒感染患儿的流行病学及临床特点。方法 选择2013年1月-2016年12月期间医院收治的非典型EB病毒感染患儿70例作为非典型EB病毒感染组,传染性单核细胞增多症患儿70例作为传染性单核细胞增多症组;统计分析患儿的年龄、性别、临床表现和实验室检查结果。结果 非典型EB病毒感染组发热、咽峡炎、淋巴结肿大、肝肿大、脾肿大率分别为60.0%、84.3%、71.4%、20.0%、15.7%,均低于传染性单核细胞增多症组的92.9%、98.6%、91.4%、51.4%、44.3%(P<0.05);非典型EB病毒感染组白细胞计数、异形淋巴细胞比例、CD_8~+低于传染性单核细胞增多症组,非典型EB病毒感染组CD_4~+、CD_4~+/CD_8~+高于传染性单核细胞增多症组(P<0.05)。结论 与传染性单核细胞增多症患儿相比,非典型EB病毒感染患儿临床症状较轻,白细胞计数和异形淋巴细胞比例升高不明显、免疫功能紊乱较轻。
Objective To investigate the epidemiology and clinical features of children with atypical Epstein-Barr virus infection. Methods Seventy patients with atypical Epstein-Barr virus (EBV) infection admitted to our hospital from January 2013 to December 2016 were selected as the atypical Epstein-Barr virus (EBV) infection group. Seventy infants with infectious mononucleosis were recruited as infectious mononuclear cells Syndrome group; statistical analysis of children with age, gender, clinical manifestations and laboratory test results. Results The rates of fever, angina, swollen lymph nodes, hepatomegaly and splenomegaly were 60.0%, 84.3%, 71.4%, 20.0% and 15.7% in patients with atypical Epstein-Barr virus infection, respectively, which were lower than that of infectious mononuclear cells The incidences of atypical Epstein-Barr virus infection were 92.9%, 98.6%, 91.4%, 51.4% and 44.3% respectively (P <0.05). The number of leucocyte, the proportion of abnormal lymphocytes and the percentage of CD8 + in atypical Epstein-Barr virus group were lower than those in infectious mononucleosis CD_4 ~ +, CD_4 ~ + / CD_8 ~ + of infectious atypical Epstein-Barr virus group were higher than that of infectious mononucleosis group (P <0.05). Conclusions Compared with children with infectious mononucleosis syndrome, children with atypical Epstein-Barr virus infection have less clinical symptoms, an insignificant increase in white blood cell count and abnormal lymphocyte count, and a mild disturbance in immune function.