论文部分内容阅读
目的:研究术前应用卡培他滨联合放疗对局部晚期直肠癌患者的安全性和有效性。方法:本院2006年1月至2006年12月收治的Ⅱ或Ⅲ直肠癌患者,共30例。放疗剂量45Gy,1.8Gy/25次,同步化疗采用卡培他滨,剂量825mg/m2,2次/天。手术在放化疗结束后6周进行。Kaplan-Meier方法评估总生存率,无疾病进展率。结果:1例患者在接受27Gy的照射剂量后死于肺栓塞。29例患者完成放化疗并完成手术。所有患者行根治性切除。中位随访期为62个月。结论:术前应用卡培他滨联合放疗对于局部晚期的直肠癌患者是行之有效的。
Objective: To study the safety and efficacy of preoperative capecitabine combined with radiotherapy in patients with locally advanced rectal cancer. Methods: The hospital from January 2006 to December 2006 admitted to Ⅱ or Ⅲ rectal cancer patients, a total of 30 cases. Radiation dose 45Gy, 1.8Gy / 25 times, simultaneous chemotherapy with capecitabine dose 825mg / m2, 2 times / day. Surgery was performed 6 weeks after the end of chemoradiation. Kaplan-Meier method to assess the overall survival rate, no disease progression rate. Results: One patient died of pulmonary embolism after receiving a dose of 27 Gy. Twenty-nine patients completed chemoradiation and completed the operation. All patients underwent radical resection. The median follow-up period was 62 months. Conclusions: Preoperative capecitabine combined with radiotherapy is effective for patients with locally advanced rectal cancer.