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目的探讨缬沙坦治疗轻中度原发性高血压病疗效及对左室肥厚的逆转作用。方法门诊确诊40例轻中度高血压病患者在停服各种心血管活性药物2周后服用缬沙坦(80mg/d)4周。所有患者在用药前及治疗后4周末复查动态血压及心脏超声。结果4周末24h收缩压、舒张压,白昼及夜间收缩压、舒张压,收缩压及舒张压负荷均显著降低,P<0.05。左室质量指数较治疗前降低,P<0.05。结论缬沙坦对轻中度高血压病患者有明显降压效果。并且可在短期内逆转左室肥厚。
Objective To investigate the efficacy of valsartan in the treatment of mild to moderate essential hypertension and reverse the effect of left ventricular hypertrophy. Methods Outpatients were diagnosed 40 mild to moderate essential hypertension patients taking valsartan (80mg / d) for 4 weeks after stopping taking all kinds of cardiovascular active drugs for 2 weeks. All patients before treatment and 4 weeks after treatment to review ambulatory blood pressure and echocardiography. Results Systolic blood pressure, diastolic blood pressure, systolic blood pressure at daytime and nighttime, diastolic blood pressure, systolic blood pressure and diastolic blood pressure were significantly decreased at 4weeks, P <0.05. Left ventricular mass index decreased compared with before treatment, P <0.05. Conclusion Valsartan has obvious antihypertensive effects on mild to moderate hypertension. And can reverse left ventricular hypertrophy in the short term.