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目的 加深对免疫缺陷性结核病的认识。方法 对两所医院 1972～ 2 0 0 0年间因免疫缺陷导致结核病而死亡的 5例患者行尸检。结果 5例胸腺发育不全或损害 ;外周淋巴结结核 ,其中3例形成巨块型病灶 ;多器官受累 ,双肺为重 ,伴血道及淋巴道播散。镜下特征为极不典型的结核病变 ,其内有大量结核分支杆菌。结论 胸腺和外周淋巴组织发育不良 ,可致抗结核分支杆菌感染能力匮乏、免疫应答不足而引起全身血行及淋巴道播散性结核病死亡。其详细的生物学潜在性紊乱机制尚待进一步探讨。
Objective To deepen the understanding of immunodeficiency tuberculosis. Methods Five patients who died of tuberculosis due to immunodeficiency between 1972 and 2000 were examined by autopsy. Results 5 cases of thymus hypoplasia or damage; peripheral lymph node tuberculosis, of which 3 cases formed massive lesions; multiple organ involvement, both lungs heavy, with blood and lymph node dissemination. Microscopic features of extremely atypical tuberculosis, which has a large number of Mycobacterium tuberculosis. Conclusion Thymus and peripheral lymphatic tissue dysplasia can lead to the lack of ability to infect Mycobacterium tuberculosis and insufficient immune response to cause systemic blood and lymphoid disseminated tuberculosis death. Its detailed mechanism of biological potential disorders remains to be further explored.