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内皮素(ET)为具有强烈缩血管作用的生物活性多肽,它对脑血管疾病的影响已引起关注;近年来认为自由基损伤在脑梗塞的发病机制中起重要作用;此外脑梗塞与红细胞变形性(RCD)及血小板聚集(PA)的关系已被人们所认识。然而目前研究多倾向于分别研究它们对脑血管疾病的影响,而研究它们在脑梗塞发病机制中的内在联系尚未有报道。本文对脑梗塞患者血浆ET、超氧化物歧化酶(SOD)、RCD及PA进行检测,以探讨其在脑缺血中的互相关系及临床意义。 1 资料和方法 1.1 研究对象 ①急性脑梗塞组:40例,男30例,女10例;平均
Endothelin (ET) is a biologically active polypeptide with a vasoconstrictor effect. It has attracted much attention for its effect on cerebrovascular diseases. In recent years, it has been suggested that free radical damage plays an important role in the pathogenesis of cerebral infarction. In addition, cerebral infarction and erythrocyte deformation The relationship between sex (RCD) and platelet aggregation (PA) has been recognized. However, most researches tend to study their influence on cerebrovascular disease separately, and there is no report on the intrinsic relationship between them in the pathogenesis of cerebral infarction. In this paper, plasma ET, superoxide dismutase (SOD), RCD and PA were measured in patients with cerebral infarction to explore their relationship in cerebral ischemia and its clinical significance. 1 Materials and Methods 1.1 Subjects ① acute cerebral infarction group: 40 cases, 30 males and 10 females; mean