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目的:探讨bcl-2、ki-67和p53在喉鳞状细胞癌中的表达及临床意义。方法:采用SP免疫组织化法检测60例喉鳞状细胞癌患者bcl-2、ki-67和p53的表达,并结合临床病理因素进行分析。结果:喉鳞状细胞癌中bcl-2、P53、Ki-67的阳性表达率分别为60.0%(36/60)、53.3%(32/60)、30.0%(18/60)。喉鳞状细胞癌患者的bcl-2、P53和Ki-67阳性表达与组织学分级及淋巴结转移密切相关,组织学分级越低,伴有淋巴结转移的喉鳞状细胞癌患者的bcl-2、P53和Ki-67阳性表达率明显高于其他组(P<0.05),但与年龄、肿瘤大小并无显著相关性(P>0.05)。结论:bcl-2、ki-67和p53是评价喉鳞状细胞癌预后的较好指标,三者联合检测有助于判断喉鳞状细胞癌的病理临床特征。
Objective: To investigate the expression and clinical significance of bcl-2, ki-67 and p53 in laryngeal squamous cell carcinoma. Methods: The expressions of bcl-2, ki-67 and p53 in 60 cases of laryngeal squamous cell carcinoma were detected by SP immunohistochemistry and analyzed with clinicopathological factors. Results: The positive rates of bcl-2, P53 and Ki-67 in laryngeal squamous cell carcinoma were 60.0% (36/60), 53.3% (32/60) and 30.0% (18/60), respectively. The positive expression of bcl-2, P53 and Ki-67 in laryngeal squamous cell carcinoma is closely related to the histological grade and lymph node metastasis. The lower the histological grade, the expression of bcl-2 in patients with laryngeal squamous cell carcinoma with lymph node metastasis, The positive rates of P53 and Ki-67 were significantly higher than those of the other groups (P <0.05), but not with age and tumor size (P> 0.05). Conclusion: bcl-2, ki-67 and p53 are good indicators for evaluating the prognosis of laryngeal squamous cell carcinoma. The combined detection of these three markers may be helpful in judging the clinical features of laryngeal squamous cell carcinoma.