论文部分内容阅读
目的：探讨合成促皮质素（ｃｏｒｔｉｃｏｔｒｏｐｉｎ）联合维生素Ｂ６辅助治疗难治性婴幼儿癫 的疗效。方法：２０例年龄为３个月至４岁的难治性癫 病儿（含婴儿痉挛症９例，其它类型癫 １１例）在原治疗方案基础上加用促皮质素，按０．０１５ｍｇ／（ｋｇ·ｄ）至０．０２５ｍｇ／（ｋｇ·ｄ）肌肉注射，第一个月 １０日为 １个周期，第一周期每日１次，第二周期隔日１次，第三周期３日１次，之后再每周用药１次连续２周至３周，总疗程２个月，使用促皮质素前用维生素Ｂ６１０日。观察用药前后的癫 发作情况、脑电图改变、血常规，肝、肾功能及血电解质变化。结果：１４例癫 发作停止，５例发作减少，１例因不良反应显终止治疗．全部病例一般情况和脑电图有改善。治疗过程中１２例病儿有低血钾、低血钙，１０例浮肿等，但血常规，肝、肾功能检查未见异常变化。结论：促皮质素联合维生素Ｂ６辅助治疗难治性婴幼儿癫 的近期疗效肯定。
Objective: To investigate the efficacy of synthetic corticotropin combined with vitamin B6 in the treatment of refractory infantile epilepsy. Methods: Twenty patients with refractory epilepsy (including 9 cases of infantile spasms and 11 cases of other types of epilepsy) aged 3 months to 4 years were treated with corticotropin supplemented with 0.015 mg / kg · d) to 0.025mg / (kg · d) intramuscularly, the first month on the 10th for a cycle, the first cycle once daily, the second cycle every other day, the third cycle on the 3rd , Then medication once a week for 2 consecutive weeks to 3 weeks, the total course of 2 months, before using corticotropin with vitamin B610. Epilepsy was observed before and after treatment, EEG changes, blood, liver and kidney function and blood electrolyte changes. Results: 14 cases of epileptic seizures stopped, 5 cases decreased seizures, 1 case was terminated due to adverse reactions was treated. The general situation and EEG improved in all cases. 12 cases of sick children during treatment hypokalemia, hypocalcemia, 10 cases of edema, but blood, liver, kidney function tests showed no abnormal changes. Conclusions: The adjuvant corticosteroid plus vitamin B6 adjuvant treatment of refractory infantile epilepsy has a positive effect in the near future.