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由猕猴研究已确定,如将垂体与下丘脑分离,结果PRL水平上升。结合L-多巴在垂体横切的动物中抑制血浆PRL水平及氯苯嗪在整体猕猴中升高PRL水平等实验表明,在猕猴中多巴胺也是下丘脑中的一种PRL抑制因素,但是在猕猴垂体柄血浆中的多巴胺及其含量对PRL分泌的调节作用,以前尚无报导,本实验测定了猕猴垂体柄血浆内多巴胺浓度,并确定此浓度是否可以说明下丘脑对PRL释放的抑制作用。首先从7只滤泡期猕猴的垂体柄中收集血浆,并用电化学液相色谱法测定多巴胺浓度,在垂体柄血浆中平均浓度是0.76ng/ml,同时收集外周血浆测定多巴胺其浓度0.1ng/ml,其次是确定了造成
It has been determined from studies in macaques that if the pituitary is separated from the hypothalamus, the PRL level rises. Experiments with L-dopa to suppress plasma PRL levels in pituitary-transected animals and elevated chlorpromazine levels in overall cynomolgus monkeys have also shown that dopamine is also a PRL inhibitor in the hypothalamus in macaques, but in macaques Pituitary stalk plasma dopamine and its regulation of PRL secretion, there is no report before, this experiment measured the plasma concentrations of dopamine in pituitary stalk of macaque monkey, and determine whether this concentration can explain the inhibitory effect of the hypothalamus on PRL release. First, plasma from seven pituitary stools of follicular stage macaques was collected and the dopamine concentration was determined by electrochemical liquid chromatography. The average concentration of puerarin in the pituitary stalk was 0.76 ng / ml. At the same time, the concentration of dopamine in the peripheral plasma was measured to be 0.1 ng / ml, followed by the determination of the cause