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慢性肝病患者的高γ-球蛋白血症发生率很高,其原因尚不十分清楚。本文报告肝硬变患者T细胞亚型与免疫球蛋白的关系。用(Moretta氏双玫瑰花形成法检测)18例肝硬变患者末梢血的T细胞亚型。结果表明,抑制性T细胞与IgA、lgM、IgD无关,而与IgG明显相关。抑制性T细胞呈现高值的肝硬变患者,其IgG亦增高;辅助性T细胞与IgG、IgA、IgD无关,而与IgM明显有关。辅助性T细胞高者,IeM亦为高值。
The high incidence of high-gamma-globulin in patients with chronic liver disease is not well understood. This article reports the relationship between T cell subsets and immunoglobulins in cirrhotic patients. T cell subtypes of peripheral blood from 18 patients with cirrhosis were assayed by (Moretta’s double rosette formation assay). The results showed that inhibitory T cells and IgA, lgM, IgD unrelated, but was significantly correlated with IgG. IgG is also increased in patients with cirrhosis who show high levels of inhibitory T cells. T helper cells are not associated with IgG, IgA, IgD, but are significantly associated with IgM. T helper high, IeM is also high.