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目的探讨胃腺癌组织学类型及浸润深度与淋巴结转移的关系。方法回顾性分析1615例胃腺癌的临床病理资料,对不同组织学类型和不同浸润深度以及淋巴结的转移率及转移个数进行统计分析。结果平均每例取淋巴结28.62个,共46227个,其中有转移的10173个,平均转移率22.01%;1615例胃腺癌有淋巴结转移的1046例,转移率为64.77%。其中TNM分期T1(M),T1(SM),T2,T3的转移率分别为2.78%,13.61%,55.59%和84.84%;组织学高分化癌转移率50.25%,低分化癌转移率78.95%,差异均有统计学意义(均P<0.001)。结论胃腺癌的转移率与组织学分类有关;随着浸润深度的增加,转移的危险性呈梯度增高。
Objective To investigate the relationship between histological type and depth of invasion and lymph node metastasis in gastric adenocarcinoma. Methods The clinical and pathological data of 1615 cases of gastric adenocarcinoma were retrospectively analyzed. The histological types, depth of invasion, lymph node metastasis and metastasis were analyzed statistically. Results The average number of lymph nodes in each case was 28.62, with a total number of 46227, of which 10,173 were metastatic and the average rate of metastasis was 22.01%. A total of 1046 cases with lymph node metastasis were found in 1615 cases of gastric adenocarcinoma with metastasis rate of 64.77%. The metastatic rates of TNM staging T1 (M), T1 (SM), T2 and T3 were 2.78%, 13.61%, 55.59% and 84.84% respectively. The rates of metastasis of histologically differentiated carcinoma were 50.25% and those of poorly differentiated carcinoma were 78.95% , The differences were statistically significant (all P <0.001). Conclusion The metastasis rate of gastric adenocarcinoma is related to the histological classification. As the depth of invasion increases, the risk of metastasis increases gradually.