对多重耐药的艾滋病病毒(HIV)感染者进行治疗的最佳方案目前尚无法确定。有人认为对常规治疗无效者可选择间隙疗法,以控制治疗时药物的毒性影响。虽然,间隙疗法可导致CD4细胞计数下降及病毒载量增加,但却可使野生型病毒再次山现且重新占有优势,当再次治疗开始时,病毒学反应较好。然而,此种治疗方法是否适合多重耐药的HIV感染者呢?作者为此进行了研究。 The best scenario for treating multi-drug resistant HIV patients is not yet known. Some people think that conventional treatment ineffective clearance therapy can be selected to control the toxicity of the drug treatment. Although clearance therapy can lead to a decrease in CD4 cell counts and increased viral load, the wild-type virus can then be re-emerged and re-taken advantage of, and virological responses are better when re-treatment begins. However, is this treatment suitable for multi-drug resistant HIV-infected patients? The authors studied this.