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回顾性分析１９８６～１９９６年间诊治的１０８例闭经溢乳（Ａ－Ｇ）综合征的临床资料，探讨其发病原因及治疗效果：１０８例Ａ－Ｇ综合征中垂体瘤３８例占３５．２％，其中有９４．７％伴高ＰＲＬ血症，部分空泡蝶鞍５例（４．７％），垂体增生１例（０．９％），甲状腺功能低下２例（１．９％），药物所致１２例（１１．１％），手术创伤１例（０．９％），特发性４９例（４５．３％）。全组６２例不孕患者经溴隐亭治疗妊娠率为５９．７％，所分娩３３个新生儿无畸形，随访７个月至８年发育均正常。垂体瘤单纯溴隐亭治疗组妊娠率为８４．０％，１８例孕妇于早孕期停药均顺利度过全孕期及分娩。结论：垂体瘤所致Ａ－Ｇ综合征除瘤体巨大引起神经压迫症状外，可首选溴隐亭治疗，肿瘤明显缩小后方可妊娠，妊娠后在严密监护下不需全孕期连续服药。
The clinical data of 108 cases of amenorrhea galactorrhea (A-G) syndrome diagnosed and treated from 1986 to 1996 were retrospectively analyzed. The causes and treatment effects were discussed: 38 cases of pituitary adenoma in 108 cases of A-G syndrome accounted for 35.2%. Among them, 94.7% had high PRL hyperlipidemia, 5 of them had a vacuolar sella (4.7%), 1 had pituitary hyperplasia (0.9%), and 2 had hypothyroidism (1.9%). The result was 12 cases (11.1%), surgical trauma in 1 case (0.9%), idiopathic in 49 cases (45.3%). The pregnancy rate of 62 cases of infertility patients treated with bromocriptine was 59.7%. 33 neonates delivered without abnormalities were normal after 7 months to 8 years of follow-up. The pregnancy rate of pituitary tumor with bromocriptine alone was 84.0%. Eighteen pregnant women successfully passed pregnancy and delivery during the first trimester. Conclusion: A-G syndrome caused by pituitary adenomas can be treated with bromocriptine in addition to the symptoms of nerve compression caused by huge tumors. The tumor can be shortened before pregnancy. After pregnancy, continuous administration of the drug is not required during the whole pregnancy.