Objective:To investigate the protective effect of extracts prepared from avocado,walnut,flaxseed and Eruca sativa seeds in a rat model of kidney dysfunction induced by intraperitoneal cisplatin.Methods:Ethanol and petroleum ether extracts mixture was prepared from each plant.Six groups of rats were conducted:control healthy,cisplatin group and four test groups where rats were given daily oral dose of each extract mixture before cisplatin injection.Different biochemical and cytogenetic parameters and kidney histopathology were determined.Acute toxicity was tested for the nutraceuticals.Total phenolic contents,faity acids(FA) and unsaponifiable matter were assessed in the extracts.Results:Walnut ethanol extract showed the highest content of total phenolic.FA analysis revealed that all the studied plants were rich in unsaturated FA.Gas-liquid chromatographic investigation of the unsaponifiable matter showed the presence of campeslerol.stigmaslerol and β—sitosterol in all the studied plants.Cisplatin treatment induced significant increase in plasma urea,creatinine and malondialdehyde along with significant reduction of plasma albumin,total protein,calalase and total antioxidant as well as reduction in creatinine clearance.Histopathological examination proved the induction of kidney dysfunction.Some sorts of chromosomal aberration and spermshape abnormalities were noticed after cisplatin treatment.Administration of extracts mixtures produced improvements in biochemical,histopathological and cytogenetic parameters.Conclusions:Administration of the studied nutraceuticals proved to possess protective role against cisplatin—induced nephrotoxicity,chromosomal aberration and abnormal sperms.All studied uutraceuticals showed complete safety. Objective: To investigate the protective effect of extracts prepared from avocado, walnut, flaxseed and Eruca sativa seeds in a rat model of kidney dysfunction induced by intraperitoneal cisplatin. Methods: Ethanol and petroleum ether extracts mixture was prepared from each plant. were conducted: control healthy, cisplatin group and four test groups where rats were given daily oral dose of each extract mixture before cisplatin injection.Different biochemical and cytogenetic parameters and kidney histopathology were determined. Acute toxicity was tested for the nutraceuticals.Total phenolic contents, faity acids (FA) and unsaponifiable matter were assessed in the extracts. Results: Walnut ethanol extract showed the highest content of total phenolic. FA analysis revealed that all the studied plants were rich in unsaturated FA. Gas-liquid chromatographic investigation of the unsaponifiable matter showed the presence of campeslerol. stimaslerol and β-sitosterol in all the studied pl ants.Cisplatin treatment induced significant increase in plasma urea, creatinine and malondialdehyde along with significant reduction of plasma albumin, total protein, calalase and total antioxidant as well as reduction as creatinine clearance. Histopathological examination proved the induction of kidney dysfunction. Home sorts of chromosomal aberration and spermshape abnormalities were noticed after cisplatin treatment. Administration of extract mixtures produced produced in biochemical, histopathological and cytogenetic parameters. Conclusions: Administration of the studied nutraceuticals proved to possess protective role against cisplatin-induced nephrotoxicity, chromosomal aberration and abnormal sperms. All studied uutraceuticals showed complete safety.