在Cu(OAc)2/TMEDA体系催化下,芳硼酸与亚磷酸二乙酯可在室温下以空气为直接氧化剂通过氧化偶联反应生成芳基膦酸酯化合物.该反应使用较为廉价低毒的铜盐为催化剂,不怕水、不怕氧,底物适用范围较广,目标产物选择性高、收率良好.因此,与已知金属催化卤代芳烃的碳-磷偶联反应相比是一种相对温和高效的合成芳基膦酸酯的方法. Under the catalysis of Cu (OAc) 2 / TMEDA system, arylboronic acid and diethylphosphite can be oxidized by air at room temperature as the direct oxidant to generate arylphosphonate compounds.The reaction uses cheaper and less toxic Copper salt as a catalyst, not afraid of water, not afraid of oxygen, a wider range of substrate applications, the target product with high selectivity, good yield.Therefore, with the known metal-catalyzed halogenated aromatics carbon-phosphorus coupling reaction is a A relatively mild and efficient method for the synthesis of aryl phosphonates.