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比较由环磷酰胺两种不同给药方式诱导小鼠血小板减少症模型的效果,并对效果较稳定的一种给药方式进行最佳造模剂量摸索,以期确定一个造模效果较好,毒副作用较低,利于观察治疗药物疗效的血小板减少症模型。模型A组,第1天尾静脉注射环磷酰胺200mg/kg,然后连续6d,每天1次以维持剂量30mg/kg腹腔注射环磷酰胺。模型B组,按150mg/kg皮下注射环磷酰胺,每天1次,连续3d。结果显示模型B组造模效果较好,故以模型B组给药方法进行剂量摸索实验。由第7天的血小板计数可知环磷酰胺低(100mg/kg)、中(120mg/kg)、高(140mg/kg)剂量均可引起血小板减少症,而低剂量组与其他组比较有高效低毒的特点,更有利于观察治疗药物的作用,可用于具有升血小板作用药物的药效学研究。
To compare the effect of cyclophosphamide induced by two different modes of administration in mice model of thrombocytopenia and to compare the best mode of dosage for one mode of administration with relatively stable effect so as to determine a better effect of modeling, Low side effects, which will help observe the therapeutic effect of thrombocytopenia model. In model group, cyclophosphamide (200mg / kg) was injected into tail vein on day 1, then cyclophosphamide was administered intraperitoneally once a day for 6 days to maintain the dose of 30mg / kg. Group B, cyclophosphamide was injected subcutaneously at 150 mg / kg once daily for 3 days. The results showed that model B group modeling effect is better, so the model B group administration method for dose exploration experiment. The platelet count at day 7 showed that low (100mg / kg), medium (120mg / kg), and high (140mg / kg) doses of thrombocytopenia all caused thrombocytopenia, whereas the low-dose group was more effective and less effective than the other groups The characteristics of poison, more conducive to the observation of the role of therapeutic drugs can be used for pharmacological effects of drugs with platelet.