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本文对28例癫痫患者的外周血单个核细胞(PBMCS)进行培养,测定了诱生的IFN-γ水平,同时检测其中17例的T细胞亚群和HLA-DR抗原,对比其相关性,并与对照组比较.结果表明癫痫患者的IFN-γ诱生能力增强,且与病因、病程、脑电图、类型、药物无关;CD8细胞显著升高,CD4/CD8显著低于对照组;HLA-DR抗原异常表达;IFN-γ与HLA-DR之间呈显著正相关,IFN-γ与CD8细胞之间无相关性,提示癫痫患者体内细胞免疫调节网络失衡,活化的淋巴细胞及其产生高水平的IFN-γ通过多种机制参与癫痫的病理过程,进一步从免疫细胞和免疫分子调节水平探讨了癫痫的免疫学发病机制.
In this paper, peripheral blood mononuclear cells (PBMCS) from 28 patients with epilepsy were cultured and the levels of IFN-γ induced were measured. T cell subsets and HLA-DR antigens were also detected in 17 cases, and their correlations were compared Compared with the control group, the results showed that IFN-γ induced ability of epilepsy patients was enhanced, and had no correlation with the etiology, course of disease, EEG, type and drug; CD8 cells were significantly increased and CD4 / CD8 was significantly lower than that of the control group; HLA- DR antigen was abnormally expressed; there was a significant positive correlation between IFN-γ and HLA-DR, but there was no correlation between IFN-γ and CD8 cells, which suggested that imbalance of cellular immunoregulatory network, activated lymphocytes and their high level of production in epilepsy patients IFN-γ participates in the pathological process of epilepsy through a variety of mechanisms, further explores the immunological pathogenesis of epilepsy from the immune cells and the regulation of immune molecules.