应用血清肌酐、脑干电位和耳蜗铺片观察卡那霉素引起的豚鼠肾功能和听功能改变及耳蜗毛细胞的病理改变,发现用药期间,在出现耳毒作用之前首先出现可逆性的肾毒作用,听功能的改变出现较迟,但一旦发生即造成永久性听力损害。实验证实肾功能的变化是耳中毒的先兆。因此,应用卡那霉素过程中,监测肾功能的改变,在发现肾功能损害时及早停用抗生素,可以防止或减轻中毒性耳聋的发生。 Application of serum creatinine, brainstem potential and cochlear implant kanamycin-induced guinea pig renal function and auditory function changes and pathological changes of cochlear hair cells and found that medication during the first occurrence of ototoxicity before the reversible nephrotoxicity Role in hearing changes in function later, but in the event of permanent hearing loss. Experiments confirmed that changes in renal function is a precursor to ototoxicity. Therefore, the application of kanamycin in the process of monitoring changes in renal function, early detection of renal impairment in the disabled antibiotics, can prevent or reduce the incidence of toxic deafness.