１９９５ 年底，发现了１ 种新型的内源性阿片肽———孤啡肽（ Ｎｏｃｉｃｅｐｔｉｏｎ 或 Ｏｒｐｈａｎｉｎ Ｆ Ｑ） ，它是１９９４ 年发现的阿片受体样（ Ｏ Ｒ Ｌ１ 或 Ｌ Ｃ１３２） 受体的内源性配体，它与受体结合后介导许多不同于经典阿片受体的生理活动。对孤啡肽的参与痛觉调节、神经传递、对离子通道和心血管系统的影响，以及拮抗剂与阻断剂、构效关系等方面的研究进展进行介绍 At the end of 1995, a new type of endogenous opioid peptide, Nociception or Orphanin FQ, was discovered and found to be an opioid receptor-like (O R L1 or L C132) receptor found in 1994 The source ligand, which binds to the receptor, mediates many physiological activities that are distinct from the classical opioid receptors. On the participation of orphanin in pain regulation, neurotransmission, ion channels and cardiovascular system, as well as the antagonist and blockers, structure-activity relationship between the research progress is introduced