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目的:了解影响辛伐他汀调脂疗效的影响因素,并为该药临床合理应用提供参考。方法:制定调脂疗效影响因素调查量表,并对176例使用辛伐他汀治疗的患者根据临床病例提供的数据填写,对包括年龄、性别、肝肾功能、合并症、合并用药等在内的14项因素进行单因素及多因素Logistic回归分析,找出影响调脂效果的要因。结果:在辛伐他汀疗效的影响因素中,年龄、肝肾功能、合并高血压为影响该药物调脂效果的要因。结论:年龄与辛伐他汀降脂疗效呈负相关,临床用药时应根据患者肝肾功能、并发症、合并用药的情况调整给药剂量,在保证疗效的同时降低不良反应发生率。
Objective: To understand the influencing factors of the effect of simvastatin on lipid-lowering and to provide a reference for its clinical application. Methods: To establish a questionnaire on the influencing factors of lipid-lowering efficacy, and to fill 176 cases of patients treated with simvastatin according to the data provided by clinical cases, including age, gender, liver and kidney function, complications, drug combination Fourteen factors were analyzed by single factor and multivariate Logistic regression to find out the factors that affect lipid regulation. Results: Among the influencing factors of simvastatin efficacy, age, liver and kidney function and hypertension were the main factors affecting the lipid regulation of the drug. Conclusion: There is a negative correlation between the age and the lipid-lowering efficacy of simvastatin. The dose should be adjusted according to the patients’ liver-kidney function, complication and drug combination, and reduce the adverse reaction rate while ensuring the curative effect.