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受试者为31～64岁的14(男10、女4)例不伴有持续性蛋白尿的原发性高血压(>150/90mmHg)病人,包括轻～中度原发性高血压13例和控制良好的恶性高血压1例.口服葡萄糖(75g)负荷试验:8例糖耐量正常(组Ⅰ),6例糖耐量降低(组Ⅱ).组Ⅱ中3例为非胰岛素依赖性糖尿病病人.卡托普利口服剂量为12.5～25mg,每8～12小时一次;调整剂量,使舒张压降至90mmHg或以下.治疗至第6和第12个月复查空腹血糖、糖耐量和胰岛素原指数
Subjects were 14 (10 males, 4 females) patients aged 31-64 years with essential hypertension (> 150/90 mmHg) without persistent proteinuria, including mild to moderate essential hypertension Cases and control of a case of malignant hypertension in patients with oral glucose (75g) load test: 8 cases of normal glucose tolerance (group Ⅰ), 6 cases of impaired glucose tolerance (group Ⅱ), 3 cases of group Ⅱ non-insulin-dependent diabetes Patients. Captopril oral dose of 12.5 ~ 25mg, once every 8 to 12 hours; adjust the dose, diastolic blood pressure dropped to 90mmHg or less.At the 6th and 12th months of treatment to review fasting blood glucose, glucose tolerance and proinsulin index