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目的探讨磁共振波谱分析 ( 1 H MRS)对肌萎缩侧索硬化 (ALS)的临床诊断价值。方法ALS病例组 30例 ,健康对照组 10例 ,同时测定大脑两侧皮层运动区的NAA、Cho、Cr。结果ALS病例组中NAA/Cr显著低于健康对照组 (P <0 .0 5) ,Cho/Cr显著高于健康对照组(P <0 .0 1)。结论NAA/Cr下降和Cho/Cr升高 ,提示ALS患者大脑皮层运动区存在神经元破坏和鞘膜功能的异常
Objective To investigate the clinical value of magnetic resonance spectroscopy (1H MRS) in the diagnosis of amyotrophic lateral sclerosis (ALS). Methods 30 cases of ALS cases and 10 cases of healthy control group were included in this study. NAA, Cho and Cr were measured at the same time. Results NAA / Cr in ALS cases was significantly lower than that in healthy controls (P <0.05), and Cho / Cr was significantly higher than that in healthy controls (P <0.01). Conclusions The decrease of NAA / Cr and the increase of Cho / Cr suggest that there are abnormalities of neuron destruction and sheath function in ALS patients