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目的:探讨DKK3表达与卵巢上皮性癌的关系。方法:采用免疫组化法检测不同卵巢组织DKK3蛋白表达水平,其中88例卵巢上皮性癌组织(以下简称卵巢癌组织)、39例卵巢良性肿瘤组织及46例正常卵巢组织。结果:DKK3在正常卵巢组织、卵巢良性肿瘤及卵巢癌组织的表达有明显差异,差异有统计学意义(P<0.05)。而DKK3表达与上皮性卵巢癌的临床病理分期及分化程度无关(P>0.05)。结论:DKK3表达水平下降与卵巢癌有关,DKK3可作为预测卵巢癌的指标。
Objective: To investigate the relationship between DKK3 expression and epithelial ovarian cancer. Methods: The expression of DKK3 protein in different ovarian tissues was detected by immunohistochemistry. Among them, 88 cases of ovarian epithelial carcinoma (hereinafter referred to as ovarian cancer), 39 cases of ovarian benign tumor and 46 cases of normal ovarian tissue. Results: The expression of DKK3 in normal ovarian tissue, benign ovarian tumor and ovarian cancer was significantly different (P <0.05). However, the expression of DKK3 was not associated with the clinicopathologic stage and differentiation of epithelial ovarian cancer (P> 0.05). Conclusion: The decreased expression of DKK3 is associated with ovarian cancer, and DKK3 may be used as a predictor of ovarian cancer.