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小胶质细胞是中枢神经系统中重要的神经免疫细胞,当中枢神经系统受到刺激后,小胶质细胞通过炎症反应来应对这种刺激,这种炎症反应在神经性疾病中具有重要作用。研究发现,小胶质细胞自噬在炎症的发生与发展中也发挥了重要作用,它能直接或间接地影响炎症反应,同时自身也被其他信号调控。自噬过程有利有弊,适当的自噬过程能促进疾病的恢复,自噬紊乱则使病情恶化,所以明确自噬的调控机制对治疗和预防相关疾病具有重要意义。本文综述了近年来自噬在小胶质细胞相关炎症中研究进展,以及其可能的调控机制,以期为相关研究人员提供一定帮助。
Microglia are important neuroimmune cells in the central nervous system. When the central nervous system is stimulated, microglia respond to such stimuli through an inflammatory response, which plays an important role in neurological diseases. The study found that microglia autophagy also plays an important role in the occurrence and development of inflammation, which can directly or indirectly affect the inflammatory response and is also regulated by other signals. The process of autophagy has both advantages and disadvantages. Appropriate process of autophagy can promote the recovery of the disease, while the disorder of autophagy worsens the condition. Therefore, it is of great significance to clarify the regulatory mechanism of autophagy in the treatment and prevention of diseases. This review summarizes the recent advances in autophagy in microglial-related inflammation and its possible regulatory mechanisms in order to provide some help to researchers.