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目的 :研究碱性成纤维细胞生长因子 (bFGF)在膀胱移行细胞癌 (BTCC)的表达及其意义。方法 :应用免疫组化ABC法检测 33例BTCC及 12例正常膀胱组织中bFGF抗原。结果 :bFGF在正常移行细胞呈阴性表达 ,在正常组织和肿瘤组织的血管内皮细胞、平滑肌细胞均呈弱阳性表达 ,肿瘤细胞呈不同程度的阳性表达且过表达率在不同病理分级、临床分期组间有显著性差异 (P <0 0 5 ) ,在单发与多发、初发与复发组间无显著性差异 (P >0 0 5 )。结论 :bFGF在BTCC浸润转移过程中起重要作用 ,可能为综合治疗提供新途径
Objective: To study the expression of basic fibroblast growth factor (bFGF) in bladder transitional cell carcinoma (BTCC) and its significance. Methods: Immunohistochemical ABC method was used to detect 33 cases of BTCC and 12 cases of normal bladder tissue bFGF antigen. Results: The expression of bFGF was negative in normal transitional cells. The expression of bFGF was weakly positive in vascular endothelial cells and smooth muscle cells in normal tissues and tumor tissues. The expression of bFGF was positive in different degree and the expression rates were different in different pathological grade, clinical stage group There was a significant difference between the two groups (P <0.05). There was no significant difference between single and multiple, primary and recurrent (P> 0.05). Conclusion: bFGF plays an important role in the invasion and metastasis of BTCC, which may provide a new approach for comprehensive treatment