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四氢原小檗碱类化合物(THPB)是一类广泛存在于中草药中的天然活性成分,其中l-THP、l-SPD等是该类活性成分中的代表化合物。THPB类化合物具有镇痛、抗药物成瘾性、抗精神分裂症等多种药理活性。综述近年THPB类化合物的药理作用研究新进展,以期为今后对THPB类化合物进一步的研究和开发利用提供参考。
Tetrahydroprotoberberines (THPB) are a kind of natural active ingredients widely found in Chinese herbal medicine. Among them, l-THP, l-SPD and so on are the representative compounds in this kind of active ingredients. THPB compounds have analgesic, anti-drug addiction, anti-schizophrenia and other pharmacological activities. This review summarizes the recent advances in the pharmacological actions of THPB compounds in order to provide reference for further research, development and utilization of THPB compounds in the future.