主动脉夹层是危险性较高的血管疾病,其发病机制及防治的研究越来越受到学者们的关注.目前主动脉夹层的动物模型主要分为在体模式和离体模式,在体模式主要包括机械建模、化学物质诱导建模和基因工程技术建模等;离体模式是指在体外模拟主动脉夹层的形成.本文主要就主动脉夹层模型的研究进展作一简要综述.“,”Aortic dissection (AD) is a high-risk vascular disease,and more and more scholars pay attention to the research of its pathogenesis,prevention and treatment.At present,the animal models of AD can be divided into in vivo models and in vitro models.In vivo models include mechanical modeling,chemical induced modeling and genetic engineering modeling.In vitro model is to simulate the formation of AD in vitro.In this paper,the research progress of AD model is reviewed.