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【目的】探讨不同干预措施对青春期肥胖型多囊卵巢综合征（PCOS ）患者性激素及其临床表现的影响。【方法】收集13～20岁青春期肥胖型PCOS患者127例，根据干预措施不同分为3组：A组（44例），生活方式调整＋炔雌醇环丙孕酮（达英‐35）＋盐酸二甲双胍治疗；B组（42例），仅用生活方式调整；C组（41例），达英‐35＋盐酸二甲双胍治疗，均干预3个月，比较各组干预后性激素水平和临床指标。【结果】三组治疗后体质量指数（BMI）均有显著性下降（ P ＜0．05），且A组BMI显著低于B组、C组（ P ＜0．05），但B组与C组比较差异无统计学意义（ P ＞0．05）。A组与C组治疗后的黄体生成素／卵泡刺激素（LH／FSH）、睾酮（T）均有显著下降（ P ＜0．05），B组治疗后LH／FSH、T 虽亦呈下降趋势，但与治疗前比较无显著性差异（ P ＞0．05）。三组治疗后月经异常改善明显，痤疮、多毛等改善不明显。【结论】生活方式调整联合达英‐35和盐酸二甲双胍通过降低PCOS患者BM I、L H／FS H及T水平，有效恢复月经，且其作用优于达英‐35和盐酸二甲双胍，但对多毛、痤疮等症状改善不明显。“,”[Objective] To explore the hormonal and symptomatic changes by different interventions for obese adolescents with polycystic ovary syndrome (PCOS) .[Methods]A total of 127 adolescents aged 13~20 years were recruited and divided randomly into three groups .That is group A ( n=44):lifestyle modification plus ethinyl estradiol cyproterone acetate (Daine‐35) plus metformin ,group B ( n=42):lifestyle modification alone and group C ( n=41):Daine‐35 plus metformin .[Results]All regimens were effective in lowering body mass index (BMI) ( P<0 .05) .And group A was more dramatic than groups B and C ( P 0 .05) .Lifestyle modification plus medication and medication alone were both effective in lowering the ratio of luteinizing hormone (LH) to follicle stimulating hormone (FSH) and reducing the level of androgen (T) .And there were significant differ‐ences ( P 0 .05) .But there was a trend of lowing LH :FSH ratio .All regi‐mens were effective in improving menstrual irregularity ,but none of them could improve acne and hirsutism ef‐fectively .[Conclusion] Lifestyle modification may lower BMI effectively ,but not T level .Lifestyle modifica‐tion plus medication medicine treatment are more effective than medication alone in lowering BMI and LH :FSH ratio and promoting regular menstruation .