论文部分内容阅读
目的:进一步完善兔VX2肝癌模型的制作使之更适合影像实验研究,同时对其进行综合评价。方法:选新西兰大白兔90只作为实验动物,兔VX2瘤株动物自身传代保存瘤肿,采用瘤块注射种植法接种于兔肝左叶。将接种动物随机分为A组(30只)、B组(30只)和C组(30只),分别于接种后7天、14天、21天行CT、DSA及病理学观察。结果:种植成功率分别为A组7%(2/30)、B组94%(28/30)、C组87%(26/30)。CT扫描较小肿瘤大部分表现稍低密度,强化明显;较大肿瘤密度不均匀,强化不明显。DSA检查成功率91%(51/56),均可见肿瘤染色。结论:兔VX2肝癌模型是较理想的影像实验研究肝癌模型,瘤块注射种植法操作简单,较经济,接种后14天的肿瘤较典型。
OBJECTIVE: To further improve the production of rabbit VX2 hepatocellular carcinoma model to make it more suitable for imaging studies, and to conduct a comprehensive evaluation. Methods: Ninety New Zealand white rabbits were selected as experimental animals. The tumor of rabbits VX2 tumor was self-passaged to preserve the tumor. The tumor was inoculated on the left lobe of rabbit liver using the tumor injection method. The animals were randomly divided into group A (n = 30), group B (n = 30) and group C (n = 30). CT, DSA and pathology were performed at 7 days, 14 days and 21 days after inoculation. Results: The success rates of planting were 7% (2/30) in group A, 94% (28/30) in group B and 87% (26/30) in group C respectively. Most of the smaller CT scan showed a slightly lower density, enhanced significantly; larger non-uniform density of the tumor, the enhancement is not obvious. The successful rate of DSA examination was 91% (51/56), all of which showed tumor staining. Conclusion: The rabbit VX2 hepatocellular carcinoma model is an ideal imaging study of liver cancer model, tumor block injection planting method is simple, more economical, 14 days after inoculation tumors typical.