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目的探讨血管紧张素转移酶(ACE)基因插入(I)/缺失(D)多态性与胃癌的相关性。方法采用聚合酶链反应(PCR)法检测181例胃癌组和198例健康对照组ACE基因I/D多态性。结果胃癌组与对照组ACE I/D基因型和等位基因分布差异不显著(P>0.05)。根据临床特征进行亚组分析,发现低分化胃癌患者中DD基因型频率明显高于高中分化(P=0.002);有转移的胃癌患者中DD基因型频率明显高于未转移(P=0.012)。结论 ACE基因I/D多态性与胃癌的分化程度和转移状态等影响胃癌预后的临床病理特征密切相关。
Objective To investigate the relationship between angiotensin transferase (ACE) gene insertion (I) / deletion (D) polymorphism and gastric cancer. Methods Polymerase chain reaction (PCR) was used to detect the I / D polymorphism of ACE gene in 181 cases of gastric cancer and 198 healthy controls. Results There were no significant differences in ACE I / D genotype and allele distribution between gastric cancer group and control group (P> 0.05). Subgroup analysis showed that the frequency of DD genotype in patients with poorly differentiated gastric cancer was significantly higher than that in high school (P = 0.002). The frequency of DD genotype in patients with metastatic gastric cancer was significantly higher than that without metastasis (P = 0.012). Conclusion The ACE gene I / D polymorphism is closely related to the clinicopathological characteristics of gastric cancer such as the differentiation and metastasis of gastric cancer.