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对１９８８年经过ＨＮＴ型疫苗初免３针，并于１９８９年加强１针的７名志愿者，于１９９７年加强１针双价疫苗后１４天采血，测定对ＨＮＴ型和ＳＥＯ型ＨＦＲＳ病毒的中和抗体。结果经加强双价疫苗的７名志愿者血清中，均检出ＨＮＴ型和ＳＥＯ型病毒的中和抗体，其中对ＨＮＴ病毒的中和抗体较高，对ＳＥＯ型病毒的中和抗体也能达到规定的要求，表明双价ＨＦＲＳ灭活疫苗可用于过去接种ＨＮＴ型疫苗人群的加强，加强接种一针可达到预防两型病毒感染的目的
Seven volunteers who underwent a 3-dose HNT vaccine in 1988 and a 1-dose needle in 1989 were boosted 14 days after the one-dose bivalent vaccine in 1997 to determine the effect on HNT-type and SEO-type HFRS viruses And antibodies. Results The neutralizing antibodies of HNT and SEO viruses were detected in the sera of seven volunteers with boosted bivalent vaccine. The neutralizing antibodies against HNT virus were higher, and the neutralizing antibodies to SEO virus could reach The requirement stated that bivalent HFRS inactivated vaccine can be used to enhance the population in the past vaccination of HNT vaccine, to strengthen the vaccination of a needle can achieve the purpose of preventing two types of virus infection