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本研究以糖尿病大鼠切口伤及海绵死腔伤为难愈伤口模型，就ＰＤＷＨＦ在改善难愈合伤口中的作用进行了探讨。致伤当日及以后连续６日，糖尿病治疗组切口伤及海绵给予ＰＤＷＨＦ２０μｌ（５ｍｇ／ｍｌ），伤后５、７、１０、１４日，测定伤口抗张力值及海绵中总ＤＮＡ、羟脯氨酸含量。结果显示：伤后５～１０日，ＰＤＷＨＦ能明显改善糖尿病伤口的愈合状况，伤后１４日可使愈合程度恢复至正常水平。提示无需进一步纯化，即可将ＰＤＷＨＦ作为促愈剂使用
In this study, diabetic rats with incisional wounds and sponge dead cavity wounds refractory wound model PDWHF in improving the role of refractory wounds were discussed. On the 6th day after injury and on the 6th day, the PDWHF 20μl (5mg / ml) was given to the wounds in the diabetes treatment group and the wound tensile strength and the total DNA in the sponge were measured on the 5th, 7th, 10th and 14th days after injury. content. The results showed that PDWHF could significantly improve the healing status of diabetic wounds on day 5 to 10 after injury, and the degree of healing could be restored to normal on the 14th day after injury. Suggesting that PDWHF can be used as a healing agent without further purification