论文部分内容阅读
目的探讨生肌膏治疗慢性溃疡的最佳换药频次及可能机制。方法 30只新西兰大白兔建立溃疡模型后分为1天换药组、2天换药组、3天换药组,每组10只。1天换药组予生肌膏每天1次换药,2天换药组每2天换药1次,3天换药组每3天换药1次,共6天。观察各组伤口分泌物重量及白细胞介素1β(IL-1β)和转化生长因子β1(TGF-β1)含量,以及伤口最终愈合时间。结果 1天换药组伤口6天分泌物总量、第6天时单位面积分泌物重量最多且IL-1β水平最高,第6天时2天换药组TGF-β1水平最高,各组间两两比较差异具有统计学意义(P<0.05)。2天换药组愈合时间最短,与其他两组比较差异具有统计学意义(P<0.05)。结论生肌膏最佳换药频次为每2天1次,其机制可能与增加分泌物TGF-β1含量有关。
Objective To investigate the optimal frequency and possible mechanism of Shengji Plaster in treating chronic ulcer. Methods Thirty New Zealand white rabbits were divided into 1-day dressing group, 2-day dressing group and 3-day dressing group with 10 animals in each group. 1 day dressing group to myogenic cream dressing 1 day, 2 days dressing group dressing every 2 days 1, 3 days dressing group dressing every 3 days 1, a total of 6 days. The wound excretion weight, interleukin 1β (IL-1β) and transforming growth factor β1 (TGF-β1) contents in wounds of each group were observed, and wound healing time was measured. Results The total secretions of the wounds in the 1-day dressing group were the highest at 6 days, with the highest secretion of IL-1β per unit area on the 6th day and the highest level of TGF-β1 on the 6th day. The levels of TGF- The difference was statistically significant (P <0.05). The healing time of the 2-day dressing group was the shortest, with statistical significance compared with the other two groups (P <0.05). Conclusion The best dressing frequency of myogenic cream is once every two days. The mechanism may be related to increasing the content of TGF-β1 in secretions.