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连续加速超分割放疗(CHART)方案,通过每日多次分封照射,缩短总治疗时间,能够提高晚期肿瘤的局控率,并可耐受。食管癌虽在放疗期间没有加速增殖的临床证据,但潜在倍增时间为5.2天,提示CHART方案可能提高其局部控制。作者回顾分析了英国Mount Vernon医院局限型食管癌54例C-HART方案和37例常规放疗结果,以评价CHART方案的疗效和毒性。CHART组:男31例,
The continuous accelerated hyperfractionated radiotherapy (CHART) program, which shortens the total treatment time by multiple daily doses of radiation, can increase the local control rate of advanced tumors and can be tolerated. Although esophageal cancer did not have clinical evidence of accelerated proliferation during radiotherapy, the potential doubling time was 5.2 days, suggesting that CHART may improve its local control. The authors reviewed retrospectively 54 cases of localized esophageal cancer in the Mount Vernon Hospital, UK, and 37 cases of conventional radiotherapy to evaluate the efficacy and toxicity of the CHART regimen. CHART group: 31 males