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巨噬细胞的许多调节和效应功能都是由分泌的多肽所介导的。肿瘤坏死因子(TNF)便是其中的一种。TNF 具有广泛的免疫调节功能和效应功能。有许多证据表明,巨噬细胞的一些功能受白细胞介素-2(IL-2)的调节。本文作者发现:提纯了的人和鼠的单核细胞在体外可被人类重组IL-2激活分泌TNF。用IL-2在体外处理人外周血单核细胞
Many of the regulatory and effector functions of macrophages are mediated by secreted polypeptides. Tumor necrosis factor (TNF) is one of them. TNF has a wide range of immunomodulatory and effector functions. There is a lot of evidence that some of the functions of macrophages are regulated by interleukin-2 (IL-2). The authors found that purified human and murine monocytes can be activated by human recombinant IL-2 to secrete TNF in vitro. Human peripheral blood mononuclear cells were treated with IL-2 in vitro