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自1976年利福定(当时称为R76—1)试制成功以后,经过许多学者进行药理、毒理的研究及临床试用,一致认为其副反应较少。在1980～1983年间全国许多单位曾应用利福定治疗肺结核三百余例治疗麻风病及其他疾病近百例。所发现的副反应主要是:肝损害、白细胞减少皮疹、皮肤搔痒等。其后在一些期刊上又有零星报导共14例。最近我刊收到关于利福定临床副反应5例的报告,现综合如下,并结合1983年后报告的14例稍加讨论。例1 朱××女 29岁工人。1983年11月10日发现右上肺结核、痰菌阳性。自12月6日接受SM+INH+RFD的治疗。12天后大便由原来每天一次
Since the success of trial production of Rifidin (then called R76-1) in 1976, many scholars have conducted pharmacological and toxicological studies and clinical trials and agreed that there were fewer side effects. In 1980 ~ 1983, many units in the country have used Rifadin to treat more than 300 cases of tuberculosis and nearly 100 cases of leprosy and other diseases. Side effects found mainly are: liver damage, leukopenia rash, skin itching and so on. Subsequent in some journals there are sporadic reports of 14 cases. Recently I received the report on clinical cases of rifampicin 5 cases are summarized below, combined with the post-1983 report of 14 cases a little discussion. Example 1 Zhu × × female 29-year-old worker. November 10, 1983 found that the right upper pulmonary tuberculosis, sputum positive. Since December 6 SM + INH + RFD treatment. 12 days after the stool from the original once a day