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目的观察微波术后联用α-2b干扰素喷雾剂治疗尖锐湿疣的临床疗效。方法将我院2009年1月至2010年12月就诊的尖锐湿疣患者78例,随机分为治疗组与对照组各39例,所有病例均应用微波手术治疗,术后治疗组外用α-2b干扰素喷雾剂,对照组外用阿昔洛韦眼液;比较分析两组的临床疗效及复发率。结果两组经4～6周治疗,总显效率治疗组为94.87%,对照组为79.49%,两组比较差异有统计学意义(P<0.05)。随访3个月,对照组复发率达58.97%,而治疗组复发率仅为15.38%,两组比较差异有统计学意义(P<0.01)。结论两组用药均可用于治疗尖锐湿疣,但微波术后外用α-2b干扰素喷雾剂疗效明显优于阿昔洛韦眼液,且复发率低,值得临床推广应用。
Objective To observe the clinical efficacy of combined use of α-2b interferon spray in the treatment of condyloma acuminatum after microwave surgery. Methods 78 patients with condylomata acuminatum treated in our hospital from January 2009 to December 2010 were randomly divided into treatment group (39 cases) and control group (39 cases). All the cases were treated with microwave surgery. Postoperative treatment group was treated with α-2b Supral spray and control group were given acyclovir ophthalmic solution. The clinical efficacy and recurrence rate were compared between the two groups. Results After 4 to 6 weeks of treatment, the total effective rate was 94.87% in the two groups and 79.49% in the control group. There was significant difference between the two groups (P <0.05). The follow-up of 3 months, the control group recurrence rate was 58.97%, while the treatment group recurrence rate was only 15.38%, the difference between the two groups was statistically significant (P <0.01). Conclusion Both groups can be used for the treatment of condyloma acuminatum. However, the effect of microwave-assisted topical α-2b interferon spray is better than that of acyclovir and the recurrence rate is low, which is worthy of clinical application.