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目的探讨胃癌患者血清IL-6、TNF-α的水平变化及临床意义。方法采用ELISA法测定35例胃癌病人血清TNF-α、IL-6水平,并与正常对照组比较。结果胃癌病人IL-6、TNF-α水平明显升高(P<0.01),并与肿瘤分期有关,肿瘤切除后血清IL-6、TNF-α水平明显降低(P<0.01)。结论胃癌病人存在细胞免疫功能紊乱,IL-6、TNF-α水平增高可能与其发生、发展有关,对胃癌病情判断及疗效观察有一定的意义。
Objective To investigate the changes and clinical significance of serum IL-6 and TNF-α in patients with gastric cancer. Methods Serum levels of TNF-α and IL-6 in 35 patients with gastric cancer were measured by ELISA, and compared with the normal control group. Results The levels of IL-6 and TNF-α were significantly increased in patients with gastric cancer (P <0.01). The levels of IL-6 and TNF-α were significantly correlated with the tumor stage (P <0.01). Conclusions There are cellular immune dysfunction in patients with gastric cancer. Elevated levels of IL-6 and TNF-α may be related to the occurrence and development of gastric cancer, which is of great significance in judging the prognosis of gastric cancer and observing the curative effect.