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目的 探讨血小板和纤维蛋白原（ＦＩＢ）在脑梗死发病中的作用。方法 观察有血栓倾向的疾病、ＴＩＡ、急性脑梗死患者及正常对照组的血小板计数（ＰＬＴ）、血小板平均体积（ＭＰＶ）、血小板聚集率（ＰｔＡｇｔ）和ＦＩＢ浓度。结果 脑梗死急性期的ＰＬＴ 明显低于正常组和其它疾病组，各疾病组的ＭＰＶ 和ＦＩＢ明显高于正常组，ＰｔＡｇｔ各组无明显差异。ＦＩＢ与欧洲卒中评分（ＥＳＳ）成正相关。结论 血小板和ＦＩＢ的变化出现在脑梗死之前，它们促进了血栓的形成，ＦＩＢ的水平可作为评价病情严重程度的指标之一。
Objective To investigate the role of platelet and fibrinogen (FIB) in the pathogenesis of cerebral infarction. Methods The thrombocytopenia, thrombocytopenia (PLT), mean platelet volume (MPV), platelet aggregation rate (PtAgt) and FIB concentration in patients with TIA, acute cerebral infarction and normal controls were observed. Results The PLT in the acute stage of cerebral infarction was significantly lower than that in the normal group and other disease groups. The MPV and FIB in each disease group were significantly higher than those in the normal group, and there was no significant difference in the PtAgt groups. FIB was positively correlated with European Stroke Scale (ESS). Conclusion The changes of platelet and FIB appear before cerebral infarction, they promote the formation of thrombus, and the level of FIB can be used as one of the indicators to evaluate the severity of the disease.