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目的 探讨三苯氧胺治疗少精症的疗效、疗程和剂量间的关系。方法 将150例患者随机分成5mg·d~(-1),10mg·d~(-1),20mg·d~(-1)共3组,分别在治疗前和每疗程后复查精液常规和血清激素水平,统计学处理。结果①治疗1疗程后,精子密度、FSH,LH,T开始升高,2～3疗程达最高峰(P<0.01),以后的疗程中,精子密度有下降趋势,FSH,LH,T一直保持高水平值;②精子活力和活动率,血清PRL,E_2治疗前后无显著变化(P>0.05);③5mg·d~(-1),10mg·d~(-1),20mg·d~(-1)各组间精液常规和血清激素水平无明显差异(P>0.05)。结论 三苯氧胺治疗少精症以剂量5mg·d~(-1),疗程不超过3个月为宜。
Objective To investigate the efficacy of tamoxifen in the treatment of oligozoospermia, the relationship between treatment and dosage. Methods 150 patients were randomly divided into 3 groups: 5 mg · d -1, 10 mg · d -1, 20 mg · d -1. Before and after each treatment, the routine and serum of semen Hormone levels, statistical analysis. Results ①Sperm density, FSH, LH and T began to increase after treatment for one course of treatment, and peaked after 2 ~ 3 courses of treatment (P <0.01). After the course of treatment, sperm density tended to decrease and FSH, LH and T remained (P> 0.05); ③The levels of sperm motility and activity, serum PRL, E 2 had no significant change before and after treatment (P> 0.05) 1) There was no significant difference between routine sperm and serum hormone in each group (P> 0.05). Conclusion tamoxifen treatment of oligozoospermia at a dose of 5mg · d ~ (-1), treatment is not more than 3 months is appropriate.