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免疫应答(immune response,Ir)是指机体受抗原刺激后,体内抗原特异性淋巴细胞对抗原分子的识别,活化,增殖,分化或失去活性潜能,并表现出一定生物学效应的全过程。 免疫耐受(immune tolerance)是机体免疫系统在接触某种抗原后产生的特异性免疫无反应状态,或称为负免疫应答,表现在当再次接触同一种抗原时,不发生可查见的反应,但对其他抗原的免疫应答仍正常存在。 混合淋巴细胞培养(mixed lymphocyte culture,MLC)或称混合淋巴细胞反应(mixed lymphocyte,MLR)常用于器官移植或骨髓移植前的组织配型,以测定受者和供体抗原相容的程度。由于MLC中淋巴细胞受到同种异型抗原的刺激而发生激活增殖和分化,并产生多种淋巴因子,促进NK,CTL和LAK等杀伤细胞的活性,因此也是免疫调节研究的模型。 移植物抗宿主病(Graft versus host disease)是由移植物中的成熟T细胞识别宿主的组织抗原而发生的排斥反应。
Immune response (Ir) refers to the body after antigen stimulation, antigen-specific lymphocytes in vivo antigen molecules recognition, activation, proliferation, differentiation or loss of activity potential, and showed a certain biological effects of the entire process. Immune tolerance is the specific immune non-responsive state of the body’s immune system upon exposure to an antigen, or negative immune response, manifested in that no visible reaction occurs when the same antigen is re-exposed , But the immune response to other antigens is still normal. Mixed lymphocyte culture (MLC), or mixed lymphocyte (MLR), is commonly used for tissue matching prior to organ transplantation or bone marrow transplantation to determine the extent to which recipient and donor antigen are compatible. MLC lymphocytes by alloantigen stimulation and activation of proliferation and differentiation, and produce a variety of lymphokines, promote NK, CTL and LAK and other killer cell activity, and therefore immunomodulatory model. Graft versus host disease is an rejection that occurs when a host’s tissue antigens are recognized by mature T cells in the graft.