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本文利用阴离子型界面活性剂十二烷基硫酸钠(SDS)和阳离子型界面活性剂十二烷基三甲基溴化铵(DTAB)形成DTAB/SDS离子对双亲分子,通过制膜、超声振荡与挤压等程序制备出阴阳离子液胞,并利用动态光散射技术探讨不同比例的胆固醇添加对液胞稳定性的影响。研究结果表明,添加胆固醇可以明显增强DTAB/SDS阴阳离子液胞的物理稳定性;但胆固醇添加量小于35mol%时并不足以使系统内的阴阳离子界面活性剂全部转换为稳定的液胞而有结晶物产生;当胆固醇添加量更少(10mol%)时能稳定存在的液胞数量更少,所以计数率明显下降。由这些结果可以推论胆固醇与阴阳离子界面活性剂在液胞的双层膜中是以固定比例排列存在,从而可以维持液胞的稳定性,因此胆固醇添加量较高时液胞稳定性较佳。
In this paper, an anionic surfactant sodium dodecyl sulfate (SDS) and a cationic surfactant dodecyl trimethyl ammonium bromide (DTAB) were used to form amphiphilic molecules of DTAB / SDS ions. And extrusion procedures were prepared for the anion and cation liquid cells, and the use of dynamic light scattering technology to explore different proportions of cholesterol on the stability of liquid sex cells. The results show that the addition of cholesterol can significantly enhance the physical stability of DTAB / SDS anion and cation liquid cells; but when the cholesterol is less than 35mol%, it is not enough to convert all the anionic and cationic surfactants in the system to stable liquid cells Crystallization occurs; when the cholesterol is added in a smaller amount (10mol%), the number of liquid cells that can stably exist is smaller, so the count rate is significantly decreased. From these results, it can be inferred that cholesterol and cationic surfactant are present in a fixed proportion in the bilayer membrane of the liquid cell so that the stability of the liquid cell can be maintained. Therefore, the stability of the liquid cell is good when the cholesterol is added in a high amount.