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给雄性ＳＤ大鼠饮用含氟化钠（１５０ｍｇ／Ｌ）及同时分别加入不同浓度亚硒酸钠（０．５、２．０和４．０ｍｇ／Ｌ）的饮水共１０周，观察氟及硒与氟联合作用对肾脏的脂质过氧化作用和微量元素铜、锌、铁含量的影响，以找出硒对氟毒性拮抗作用的最佳水平。结果表明，氟可使大鼠血清和肾组织脂质过化物含量明显增加，微量元素铜、锌、铁代谢紊乱。２．０ｍｇ／Ｌ亚硒酸钠对氟诱导的脂质过氧化具有显著的拮抗作用，对微量元素的改变也有明显的作用，而０．５和４．０ｍｇ／Ｌ时对氟毒性的拮抗作用均较差。因此，可以认为２．０ｍｇ／Ｌ亚硒酸钠是本实验条件下拮抗氟致肾损害的最佳水平。
Male SD rats were drank with sodium fluoride (150mg / L) and different concentrations of sodium selenite (0.5, 2.0 and 4.0mg / L) for 10 weeks respectively. The effects of fluoride and selenium Combined with fluorine on the lipid peroxidation of the kidney and trace elements copper, zinc and iron content in order to find out the best level of selenium antagonism of fluoride toxicity. The results showed that fluoride could significantly increase the content of lipid peroxides in serum and kidney of rats, and the metabolic disturbance of trace elements copper, zinc and iron. Sodium selenite at 2.0 mg / L had significant antagonistic effect on fluoride-induced lipid peroxidation and had obvious effect on the change of trace elements. At 0.5 and 4.0 mg / L, the antagonism to fluoride toxicity Are poor. Therefore, it can be considered 2.0mg / L sodium selenite is the optimal level of antagonizing fluoride-induced renal damage under the experimental conditions.