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目的:分析环后癌手术治疗疗效,总结环后癌手术切除及咽喉功能重建经验。方法:回顾性分析2010年1月至2017年5月山东大学齐鲁医院手术治疗的45例环后癌患者的临床资料,其中男性39例,女性6例,年龄41~78岁。TNM分期T1 2例,T2 13例,T3 23例,T4 7例;N0 12例,N1 8例,N2 25例;临床分期Ⅰ期1例,Ⅱ期4例,Ⅲ期10例,Ⅳ期30例;均无远处转移。所有患者均行颈部淋巴清扫术,安全界限完整切除肿瘤后,使用残余黏膜、胸大肌肌皮瓣、喉气管组织瓣、胃上提胃代食管等方法进行咽功能重建,采用会厌、胸骨舌骨肌筋膜瓣、甲状软骨膜进行喉腔的修复。Kaplan-Meier生存曲线法统计3年及5年生存率。结果:45例患者术后行单纯放疗23例,同步放化疗13例。所有患者均随访3年以上,3年总生存率60.5%,5年总生存率49.0%,喉功能保留率44.4%(20/45)。颈部淋巴结阳性率73.3%(33/45),区域淋巴结转移与生存率的关系比较差异有统计学意义(χn 2=4.364,n P=0.037)。n 结论:选择合适的肿瘤切除入路及方式,充分利用各种组织瓣进行咽喉功能重建,可以实现在彻底切除肿瘤前提下的喉功能最大限度的保留,从而提高环后癌患者的生存质量。“,”Objective:To evaluate the oncologic and functional outcomes of postcricoid carcinoma treated by surgical treatment, and to summarize our clinical experience in surgical treatment and reconstructive techniques.Methods:Medical files of 45 patients were collected and retrospectively analyzed. The patients received surgical treatments between January 2010 and May 2017 in the Qilu Hospital of Shandong University, including 39 males and 6 females, the age ranged from 41 to 78 years old. T1, T2, T3 and T4 staging tumors represented respectively for 2,13,23 and 7 cases. And cervical metastasis was histologically identified in 33 cases (8 for N1 and 25 for N2). Advanced staging patients (10 in Stage Ⅲ and 30 in Stage Ⅳ) accounted for 88.9% of the cohort, while early staging cases (1 in Stage Ⅰand 4 in Stage Ⅱ) for 10.1%. All patients received cervical lymph node dissection. After tumor excision without compromising margins, hypopharyngeal functions were reconstructed by residual mucosa, pectoralis major myocutaneous flap, laryngotracheal tissue flap or gastric tissue flap, and laryngeal functions were reconstructed by epiglottis, sternohyoid myofascial flap or thyroid perichondrium. Survival rates were analyzed by the Kaplan-Meier method.Results:Postoperatively 23 patients received radiotherapy and 13 patients received chemoradiotherapy. All patients were followed up for more than 3 years. Total 3-year and 5-year survival rates were 60.5% and 49.0%, respectively. Patients obtaining the conservation of laryngeal functions accounted for 44% (20/45) of all cases. The neck lymph node positive rate was 73.3%(33/45), and log-rank test demonstrated that cervical lymph node metastasis was significantly associated with prognosis of patients (χn 2=4.364, n P=0.037).n Conclusion:Appropriate surgical approaches and excision methods and comprehensive application of flaps are critical to precise tumor excision and reconstruction of laryngeal functions, thereby improving the quality of life of patients with posterior carcinoma.