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[目的]探讨云南白药联合蛇毒血凝酶对上消化道出血治疗效果及并发症的影响。[方法]将鞍钢集团总医院诊治的248例非静脉曲张上消化道出血患者随机分为4组,对照组63例给予质子泵抑制剂;血凝酶组65例在对照组的基础上加用蛇毒血凝酶治疗;云南白药组60例在对照组基础上给予云南白药口服;联合治疗组60例在对照组基础上给予云南白药联合蛇毒血凝酶。比较4组在上消化道出血24h、48h、72h治疗有效率及总有效率,同时观察4组在消化道出血并发症方面差别,尤其是缺血性脑血管病、冠状动脉粥样硬化性心脏病方面的差别。[结果]联合治疗组在24h治疗有效率方面治疗组优于其他组,在48h、72h治疗有效率及总有效率方面差异无统计学意义。在缺血性脑血管病、冠心病并发症方面4组差异无统计学意义。[结论]在质子泵抑制剂基础上云南白药联合蛇毒血凝酶治疗非静脉曲张上消化道出血可获得满意疗效,不良反应少,云南白药组与对照组差异无统计学意义。
[Objective] To investigate the effect of Yunnan Baiyao combined with venom hemagglutinin on the therapeutic effect and complications of upper gastrointestinal bleeding. [Methods] A total of 248 patients with non-variceal upper gastrointestinal bleeding diagnosed and treated at General Hospital of Angang were randomly divided into 4 groups, 63 patients in the control group were given proton pump inhibitor; 65 patients in the hemagglutinin group were added on the basis of the control group Snake venom hemagglutinin treatment; 60 cases of Yunnanbaiyao group were given Yunnan Baiyao oral; 60 cases of combined treatment group were given Yunnanbaiyao combined with snake venom hemagglutinin on the basis of the control group. Four groups were compared in the treatment of upper gastrointestinal bleeding 24h, 48h, 72h treatment efficiency and total effective rate, while 4 groups were observed in gastrointestinal bleeding complications, especially ischemic cerebrovascular disease, coronary atherosclerotic heart Disease differences. [Result] Compared with other groups, the treatment group was superior to the other groups in the treatment efficiency of 24h, but there was no significant difference in the treatment efficiency and the total effective rate at 48h and 72h. In ischemic cerebrovascular disease, coronary heart disease complications in the four groups no significant difference. [Conclusion] On the basis of proton pump inhibitor, Yunnanbaiyao combined with snake venom hemagglutinin in the treatment of non-variceal upper gastrointestinal bleeding can be obtained with satisfactory curative effect, less adverse reactions, Yunnanbaiyao group and the control group no significant difference.