论文部分内容阅读
目的分析血清癌胚抗原(CEA)、细胞角蛋白19片段(CYFRA21-1)、神经元特异性烯醇化酶(NSE)、糖类抗原125(CA125)和糖类抗原242(CA242)联合检测对肺癌诊断准确率的影响。方法选取2015年6月至2016年12月间南通市肿瘤医院收治的102例肺癌患者作为研究组,选取同期医院经胸片或胸部CT诊断为肺良性疾病的102例患者作为对照组;对两组患者进行血清CEA、CYFRA21-1、NSE、CA125和CA242联合检测,比较两组患者五种血清肿瘤标志物指标变化。结果研究组患者血清CEA、CYFRA21-1、NSE、CA125和CA242水平均较对照组升高明显,差异均有统计学意义(均P<0.05)。研究组患者在疾病不同分期内血清CEA、CYFRA21-1、NSE、CA125和CA242水平变化显著(P<0.05)。联合检测血清CEA、CYFRA21-1、NSE、CA125和CA242标志物水平,灵敏度为94.2%,特异性为76.5%,准确率为69.4%;单一检测血清CEA、CYFRA21-1、NSE、CA125和CA242灵敏度分别为64.2%、68.3%、51.9%、54.7%和55.6%,特异性分别为87.5%、61.2%、81.2%、81.6%和79.6%,准确率分别为59.7%、41.6%、42.4%、42.1%和61.2%;联合检测灵敏度与准确率均高于单一检测,差异均有统计学意义(均P<0.05)。结论应用血清CEA、CYFRA21-1、NSE、CA125和CA242联合检测,可提升肺癌诊断准确率,有助于早诊断、早治疗。
Objective To analyze the association between CEA, CYFRA21-1, NSE, carbohydrate antigen 125 (CA125) and carbohydrate antigen 242 (CA242) Impact of lung cancer diagnosis accuracy. Methods A total of 102 patients with lung cancer who were admitted to Nantong Cancer Hospital from June 2015 to December 2016 were selected as study group and 102 patients with benign lung disease diagnosed by chest CT or chest CT at the same period were selected as control group. Group of patients with serum CEA, CYFRA21-1, NSE, CA125 and CA242 joint detection, two groups of patients with five serum tumor marker index changes. Results The serum levels of CEA, CYFRA21-1, NSE, CA125 and CA242 in the study group were significantly higher than those in the control group (all P <0.05). The levels of serum CEA, CYFRA21-1, NSE, CA125 and CA242 in the study group were significantly different at different stages (P <0.05). The combined detection of serum CEA, CYFRA21-1, NSE, CA125 and CA242 markers showed a sensitivity of 94.2%, specificity of 76.5% and accuracy of 69.4%. Serum CEA, CYFRA21-1, NSE, CA125 and CA242 Respectively, which were 64.2%, 68.3%, 51.9%, 54.7% and 55.6%, respectively, with the specificity of 87.5%, 61.2%, 81.2%, 81.6% and 79.6% respectively, with the accuracy of 59.7%, 41.6%, 42.4% and 42.1 % And 61.2%, respectively. The sensitivity and accuracy of combined detection were higher than those of single detection (all P <0.05). Conclusions Combined detection of serum CEA, CYFRA21-1, NSE, CA125 and CA242 can improve the diagnostic accuracy of lung cancer and help early diagnosis and early treatment.