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本研究分二批进行,第一批用成年雄性大鼠每天接受X射线全身照射50mGy/次和100mGy/次,剂量率为15mGy/分,6次/周,共照5周(30次),累积剂量分别为1.5Gy和3.0Gy。受照大鼠睾丸重量在停照后4周内呈持续性减轻,以照射剂量大,停照时间长者,减轻最明显(相当于对照43.9%)。睾丸中cAMP含量于停照后1周升高,以100mGy组明显(P<0.01),停照后2周仍显著高于对照(P<0.05),停照后4周回降到正常较低水平。而血浆和肾上腺中cAMP和胸上腺中cGMP含量无明显变化。第二批实验动物条件与第一批相同,每天接受16.3mGy,~(60)Coγ射线全身照射,剂量率为45.3pGy/分,6次/周,每次照射6小时,在照射6、10、14、18、22周,累积剂量分别为0.59、0.98、1.37、1.76、2.15Gy时与相应对照组比较,垂体、睾丸中cAMP含量及睾丸重量无显著差别,证实慢性小剂量全身照射对睾丸组织的损伤主要取决于剂量率大小,剂量率愈大损伤愈明显。
The first batch of adult male rats received 50 mGy / time and 100 mGy / time of X-ray whole body irradiation every day. The dose rate was 15 mGy / min., 6 times / week for 5 weeks (30 times) Cumulative doses were 1.5 Gy and 3.0 Gy, respectively. The weight of testis in irradiated rats showed a sustained reduction within 4 weeks after the suspension, with the most obvious reduction (equivalent to 43.9% of the control) at the higher irradiation dose and the longer duration of suspension. The content of cAMP in testis increased at 1 week after stopping, and was significantly higher at 100 mGy (P <0.01). The level of cAMP in testis was still significantly higher than control at 2 weeks after stopping (P <0.05) . The plasma and adrenal cAMP and cGMP content in the thymus no significant change. The second group of experimental animals were given the same conditions as the first group and received 16.3mGy and 60Coγray whole-body irradiation daily at the dose rate of 45.3pGy / min and 6 times / week for 6 hours. , 14,18,22 weeks, the cumulative dose were 0.59,0.98,1.37,1.76,2.15Gy compared with the corresponding control group, pituitary, testicular cAMP content and testicular weight was no significant difference confirmed that chronic small doses of whole body irradiation on the testes Tissue damage mainly depends on the size of the dose rate, the greater the dose rate damage more obvious.